IN THE SPOTLIGHT Mass Cytometry: A High-Throughput Platform to Visualize the Heterogeneity of Acute Myeloid Leukemia

نویسندگان

  • Priscilla Do
  • John C. Byrd
چکیده

Division of Hematology, Department of Medicine, The Ohio State University, Columbus, Ohio. Corresponding Author: John C. Byrd, The Ohio State University, B304 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210. Phone: 614-293-9321; Fax: 614-293-7526; E-mail: [email protected] doi: 10.1158/2159-8290.CD-15-0905 ©2015 American Association for Cancer Research. Summary: Behbehani and colleagues use mass cytometry to profi le the heterogeneity of acute myeloid leukemia (AML ) as compared with normal hematopoiesis. By using this approach and characterizing leukemic stem cells, important differences in response to chemotherapy between AML subsets can potentially be explained and new targeted approaches considered. Cancer Discov; 5(9); 912–4. ©2015 AACR .

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Diagnosis of Myeloid Sarcoma of Female Breast by Routine Microscopic Findings Using Immunohistochemical Method, Bone Marrow Aspiration and Flow Cytometry

Myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (AML). The tumor mass may precede or occur concurrently with AML, CML, myeloproliferative disorders, and/or myelodysplastic syndromes. Histologically, it looks like a large cell lymphoma and can be misdiagnosed. A case refe...

متن کامل

Geographic Heterogeneity of the AML1-ETO Fusion Gene in Iranian Patients with Acute Myeloid Leukemia

Background: The human AML1 gene, located on chromosome 21, can be fused to the AML1- eight-twenty-one (ETO) oncoprotein on chromosome eight, resulting in a t(8;21)(q22;q22) translocation. Acute myeloid leukemia (AML) associated with this translocation is considered a distinct AML with a favorable prognosis. Due to the various incidences of the translocation, which is associated with geographic ...

متن کامل

Unilateral Ptosis as Initial Manifestation of Acute Myeloid Leukemia

Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increa...

متن کامل

Lipid profile and oxidized lipoprotein levels in patients with acute myeloid leukemia

Background: Acute myeloid leukemia (AML) is blood and bone marrow malignancy. Low-density oxidative lipoprotein (oxLDL) is a pro-inflammatory factor that has free radicals in its structure. OxLDL levels are also rising in diseases such as diabetes, cardiovascular disease, and some cancers. Studies have shown that oxLDL and dyslipidemia are more common in patients with various cancers. This stud...

متن کامل

Prognostic Value of EVI1 Expression in Pediatric Acute Myeloid Leukemia: A Systematic Review

Acute myeloid leukemia (AML) as a distortion of blood cells involves the differentiation of hematopoietic stem cells. Several studies established the irregular overexpression of specific genes is a common finding in patients with AML. The ectopic viral integration site-1 (EVI1) gene is a proto-oncogene subject to alternative splicing, and encodes a zinc-finger protein that acts as a tr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015